人腸癌組織
人乳腺癌組織
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產(chǎn)品中心實(shí)現(xiàn)“精準(zhǔn)醫(yī)療踐行者”的理念
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解決方案多應(yīng)用場(chǎng)景的一站式空間生物學(xué)解決方案
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技術(shù)服務(wù)完善的多組學(xué)（DNA\RNA\蛋白）檢測(cè)平臺(tái)
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關(guān)于我們北京菲諾維康生物科技有限公司
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資訊動(dòng)態(tài)
空間多組學(xué)技術(shù)服務(wù)
技術(shù)背景
2022年空間多組學(xué)技術(shù)被Nature評(píng)為七大“顛覆性”技術(shù)之一，是將基因組、轉(zhuǎn)錄組、蛋白質(zhì)組以及代謝組的檢測(cè)結(jié)果與組織原位信息相結(jié)合，重塑空間立體結(jié)構(gòu)內(nèi)相關(guān)組學(xué)信息的定位分布情況。隨著多個(gè)免疫治療藥物的獲批，腫瘤免疫療法日趨成熟，人們?cè)絹?lái)越多地關(guān)注組織微環(huán)境的概念及其在腫瘤免疫治療中的作用。腫瘤細(xì)胞可以通過(guò)釋放細(xì)胞外信號(hào)影響周邊的微環(huán)境，促進(jìn)腫瘤血管增生和抑制周邊的免疫細(xì)胞，而腫瘤微環(huán)境中的免疫細(xì)胞及因子又可以影響腫瘤細(xì)胞的生長(zhǎng)(見(jiàn)下圖)。
服務(wù)內(nèi)容
空間多組學(xué)技術(shù)眾多，從高通量空間轉(zhuǎn)錄組和蛋白組到低通量RNA原位檢測(cè)技術(shù)和多重?zé)晒饷庖呓M化技術(shù)，不同方法學(xué)在各自應(yīng)用領(lǐng)域發(fā)揮著獨(dú)特的作用。菲諾維康擁有完整的空間多組學(xué)平臺(tái)，集研發(fā)、實(shí)驗(yàn)室服務(wù)以及臨床應(yīng)用開(kāi)發(fā)于一體，提供多組學(xué)（DNA\RNA\蛋白）一站式空間生物學(xué)解決方案。
應(yīng)用方向
案例展示
空間表型分析可以將標(biāo)記物組合（panel）分為幾大類：鑒別T細(xì)胞及其亞型（如殺傷性T細(xì)胞、輔助型T細(xì)胞）在腫瘤中的分布；鑒別M1型/M2型巨噬細(xì)胞在腫瘤中的分布；聚焦B細(xì)胞不同亞型（如CD20，CD21為代表的B細(xì)胞亞型）以及三級(jí)淋巴結(jié)構(gòu)在腫瘤中的分布；關(guān)注更多種免疫細(xì)胞類型，如將NK細(xì)胞、樹(shù)突細(xì)胞引入到panel中，觀察不同免疫細(xì)胞在腫瘤中的分布；聚焦結(jié)合腫瘤標(biāo)記物以及免疫檢測(cè)點(diǎn)，觀察不同幾大細(xì)胞類型（腫瘤細(xì)胞、B細(xì)胞、T細(xì)胞、巨噬細(xì)胞等）在腫瘤中的分布。
人黑色素瘤組織
人肺癌組織
參考文獻(xiàn)
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